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KMID : 0350519920450010327
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Journal of Catholic Medical College
1992 Volume.45 No. 1 p.327 ~ p.336
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Effect of Caffeine on Haloperidol-induced Catalepsy in the Rat
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Abstract
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Caffeine is one of the most widely consumed central nervous system stimulants and constitutes main component of beverages that are part of our meals. A lot of pasychiaric patients often consume large amounts of caffeine with neuroleptics that are
dopamine antagonists and induce catalepsy. Caffeine has effect of dopamine agonism based on stimlant effect of caffeine and may effect on neuroleptic-induced catalepsy. We investigated the effect of caffeine on the catalepsy induced by
haloperidol
in
the rats.
@ES The results were as follows:
@EN 1) Caffeine produced a significant decrease of catalepsy induced by haloperidol in 30 min. after single administration of caffeine. The significant decreases of catalepsy in relation to time and caffeine doses were fund at caffeine 10mg/kg
and
20mg/kg groups.
2) The degree of catalepsy induced by haloperidol was not modified with continuous administration of caffeine for 7 consecutive days, suggesting the tolerance of caffeine was minimal.
These results suggest that the caffeine acts as a dopamine receptor agonist involving a competitive antagonism to neuroleptics, and the consumption of caffeine containing beverages should be avoided in patients treated with neuroleptics.
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KEYWORD
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